Home > Journals > Journal of Neurosurgical Sciences > Past Issues > Journal of Neurosurgical Sciences 2001 December;45(4) > Journal of Neurosurgical Sciences 2001 December;45(4):228-31

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

JOURNAL OF NEUROSURGICAL SCIENCES

A Journal on Neurosurgery


Indexed/Abstracted in: e-psyche, EMBASE, PubMed/MEDLINE, Neuroscience Citation Index, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,651


eTOC

 

CASE REPORTS  


Journal of Neurosurgical Sciences 2001 December;45(4):228-31

language: English

Cerebellar metas­ta­sis ­from ­clear ­cell sar­co­ma of the kid­ney. A ­case ­report ­with immu­no­his­to­chem­is­try

Dundar E. 1, Arslantas A. 2, Acikalin M. F. 1, Tel E. 2

1 Pathology Department, Osmangazi University Medical Faculty, Eskisehir, Turkey;
2 Neurosurgery Department, Osmangazi University Medical Faculty, Eskisehir, Turkey


PDF  


The aim of ­this ­study was to ­describe a ­child ­with a ­right cer­e­bel­lar hem­i­sphere metas­ta­sis ­from pri­mary ­clear ­cell sar­co­ma of the kid­ney with­out evi­dence of ­bone metas­ta­ses, and to inves­ti­gate the immu­no­his­to­chem­i­cal fea­tures of pri­mary and met­a­stat­ic ­tumors. A 12-­month old boy was admit­ted our hos­pi­tal due to an abdom­i­nal ­mass. Abdominal com­put­ed tomog­ra­phy ­revealed a ­large ­right ­renal ­tumor. Tumor was ­removed ­with neph­rec­to­my. Histopathologic exam­ina­tion of ­tumor ­revealed ­clear ­cell sar­co­ma of the kid­ney. The ­patient ­received radio­ther­a­py and chem­o­ther­a­py in post­op­er­a­tive peri­od. He suf­fered ­from ­gait dis­tur­bance and con­fu­sion 8 ­months lat­er. A com­put­ed tomog­ra­phy ­scan ­revealed a ­tumor ­that was ­enhanced ­with con­trast medi­um at ­right cer­e­bel­lar hem­i­sphere con­com­i­tant ­with ven­tric­u­lar enlarge­ment. After ven­tri­cu­lo-per­i­to­neal shunt­ing pro­ce­dure, ­tumor was ­excised total­ly and his­to­path­o­log­ic diag­no­sis ­showed metas­ta­sis of ­clear ­cell sar­co­ma of the kid­ney. Immunohistochemi-cally vimen­tin, ­actin, ­desmin, neu­ron spe­cif­ic eno­lase, cyto­ker­a­tin, P 53, Ki-67 and P-170 ­were per­formed ­using for­mal­in ­fixed, par­af­fin embed­ded sec­tions. Both of the ­tumors ­were pos­i­tive for vimen­tin and neg­a­tive for ­desmin, ­actin, neu­ron spe­sif­ic eno­lase, cyto­ker­a­tin and P 53. Scattered ­nuclei ­were ­stained by Ki-67 in pri­mary and met­a­stat­ic cer­e­bel­lar ­tumor. Both pri­mary and met­a­stat­ic ­tumors ­were neg­a­tive for p53 and P-170. The treat­ment con­sist­ed of sur­gery, radio­ther­a­py and chem­o­ther­a­py. The ­patient is ­alive and ­well with­out evi­dence of recur­rence 16 ­months ­after sec­ond sur­gery. Clear ­cell sar­co­ma of the kid­ney is ­most com­mon­ly asso­ciat­ed ­with ­bone metas­ta­sis. Cerebellar metas­ta­sis of ­clear ­cell sar­co­ma of the kid­ney is ­very unusu­al. To the ­best of our knowl­edge, ­this ­patient is sec­ond ­case in the English lit­er­a­ture. With ­review of the lit­er­a­ture, our immu­no­his­to­chem­i­cal find­ings sup­port the the­o­ry ­that ­relaps and metas­ta­sis of pri­mary ­clear ­cell sar­co­ma of the kid­ney are not relat­ed ­with ­increase of aggres­sive­ness.

top of page

Publication History

Cite this article as

Corresponding author e-mail