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CURRENT ISSUEJOURNAL OF NEUROSURGICAL SCIENCES

A Journal on Neurosurgery


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ORIGINAL ARTICLES  


Journal of Neurosurgical Sciences 2000 December;44(4):203-10

language: English

Value of MIB-1 label­ling ­index (LI) in gli­o­mas and its cor­re­la­tion ­with oth­er prog­nos­tic fac­tors. A cli­nic­o­path­o­log­ic ­study

Rodriguez-Pereira C. 1, Suarez-Penaranda J. M. 2, Vazquez-Salvado M. 5, Sobrido M. J. 3, Abraldes M. 2, Barros F. 4, Forteza J. 2

1 Department of Pathology, Hospital General de Castellón, Castellón, Spain;
2 Department of Pathology, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain;
3 Department of Neurology, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain;
4 Department of Molecular Medicine, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain;
5 Department of Preventive Medicine, Hospital General del Insalud, Soria, Spain


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Background. In ­recent ­years, the mono­clo­nal anti­body MIB-1 has ­become the ­main fac­tor to meas­ure the pro­life­ra­tive poten­tial of ­glial ­tumors. This anti­body is equiv­a­lent to Ki-67, ­which is ­used in fro­zen sec­tions, and ­reacts ­with a nucle­ar pro­tein ­that is ­expressed ­through the ­cell ­cycle. We ­have inves­ti­gat­ed the val­ue of MIB-1 Labelling Index (LI) as an inde­pen­dent prog­nos­tic fac­tor in gli­o­mas and its rela­tion­ship ­with clin­i­cal and path­o­log­i­cal param­e­ters.
Methods. MIB-1 LI was deter­mined in 139 gli­o­mas by ­using the Streptavidin-Biotin Complex (SBC) immu­no­his­to­chem­i­cal meth­od. MIB-1 LI immu­no­reac­tiv­ity was meas­ured ­with an auto­mat­ic ­cell count­ing ­system. Survival was stud­ied by ­using the Kaplan-Meier bivar­i­ant anal­y­sis and Cox mul­ti­var­i­ant regres­sion.
Results In bivar­i­ant anal­y­sis MIB-1 LI ­increased ­with age, his­to­log­i­cal ­grade and a supra­ten­to­ri­al lat­er­al loca­tion. Only ­size and ­tumor ­grade ­were sig­nif­i­cant in Cox regres­sion.
Conclusions. Perhaps ­this pro­life­ra­tion mark­er is influ­enced by ­many fac­tors ­which ­reduce its val­ue as an iso­lat­ed prog­nos­tic param­e­ter.

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