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Journal of Neurosurgical Sciences 2000 September;44(3):123-7

Copyright © 2000 EDIZIONI MINERVA MEDICA

language: English

Non-hindbrain-related syringomyelia. Obstruction of the subarachnoid space and the central canal in rats. An experimental study

Cosan T. E. 1, Tel E. 1, Durmaz R. 1, Gulec S. 2, Baycu C. 3

1 Department of Neurosurgery, Osmangazi University, Eskisehir, Turkey; 2 Department of Anesthesiology, Osmangazi University, Eskisehir, Turkey; 3 Department of Histology and Embryology, Osmangazi University, Eskisehir, Turkey


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Background. The aim is to deter­mine the mech­a­nism of non-hind­brain-relat­ed syrin­gom­ye­lia in experi­men­tal mod­els. The ­effects of obstruc­tion of cen­tral ­canal and sub­arach­noid ­space on occur­rence of cav­ities ­were dis­cussed.
Methods. 31 Sprague-Dawley ­rats ­were ­used ­with ­eight (Group D) as a con­trol. In 10 ­rats (Group A) 1.5 µl kao­lin was micro­in­ject­ed ­into the dor­sal col­umns and cen­tral ­gray mat­ter of the spi­nal ­cord at the lev­el of Th6-10. In 10 ­rats (Group B) 0.1 cc kao­lin was inject­ed ­into the sub­arach­noid ­space at the ­same lev­el. In 3 ­rats (Group C), 1.5 µl kao­lin was admin­is­tered ­into ­both dor­sal mid­line of the spi­nal ­cord and the sub­arach­noid ­space.
Results. In Group A, his­to­log­i­cal exam­ina­tion ­revealed cys­tic cav­ity and dil­a­ta­tion of the cen­tral ­canal in ­five ­rats; denud­ed epen­dy­mal ­line and mul­ti­cys­tic for­ma­tions in epen­dy­mal and per­i­epen­dy­mal are­as in sev­en ­rats. In Group B, denud­ed epen­dy­mal ­line in ­three ­rats and micro­cys­tic for­ma­tions in epen­dy­mal and per­i­ependymal are­as in ­four ­rats ­were ­revealed. In Group C, ­there ­were micro­cys­tic for­ma­tions in two ­rats and ­syrinx cav­ity in one rat.
Conclusions. Developments lead­ing to occur­rence of cav­ities are ­focused on the cen­tral ­canal in all ­groups. These mod­els indi­cate ­that the CSF-­flow is ­from the sub­arach­noid ­space to the cen­tral ­canal lead­ing to chang­es of cav­ities. In cas­es of obstruc­tion of the sub­arach­noid ­space or the cen­tral ­canal, the occur­rence of ­syrinx cav­ity initial­ly is due to ­increased CSF (cere­bro­spi­nal ­fluid) pres­sure in the cen­tral ­canal. Flow chang­es in spi­nal ­cord is indi­cat­ed by ­this ­study.

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