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MINERVA UROLOGICA E NEFROLOGICA

A Journal on Nephrology and Urology


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Minerva Urologica e Nefrologica 2017 Jul 12

DOI: 10.23736/S0393-2249.17.02874-0

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Leisure time physical activity and risk of prostate cancer: a dose-response meta-analysis

Feng LIU 1, Jing WANG 1 , Hai-Long WU 1, Hui WANG 2, Jian-Xiang WANG 1, Rui ZHOU 1, Zhi ZHU 3

1 Department of Surgery, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; 2 Department of Gastroenterology, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; 3 Department of Epidemiology and Biostatistics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China


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INTRODUCTION: Physical activity (PA) may be a protect factor against prostate cancer (Pca). We aim to investigate and establish the potential relationship between leisure-time PA and Pca.
EVIDENCE ACQUISITION: PubMed, Embase databases were searched for eligibly studies (cohort) before Aug-11, 2016. We conducted a meta-analysis to pool the dose-specific effects between leisure-time PA and Pca. Subgroup analysis was employed to see the potential variation among each group. Sensitivity analysis was used to examine whether our results were stable.
EVIDENCE SYNTHESIS: We totally identified 21 cohort studies with 803,872 numbers of subjects and 28,707 Pca cases. In our meta-analysis, no obvious evidence of non-linear relationship was observed. The RRs of each 500 MET-s/week increment of leisure-time PA was 1.00 (95%CI: 0.99, 1.01) for total Pca, 1.00 (95%CI: 0.98, 1.01) for local Pca, and 1.00 (95%CI: 0.98, 1.02) for advanced Pca. In subgroup analysis, for Americans, the RR of each 500 MET-s/week increment of leisure-time PA was 1.00 (95%CI: 0.99, 1.01); and for Europeans the RR was 1.00 (95%CI: 0.99, 1.01). Sensitivity analysis suggested our results were stable.
CONCLUSION: Current evidence based on observational studies suggests no obvious association between leisure-time activity and risk of prostate cancer, regardless of total Pca, local Pca, or advanced Pca.


KEY WORDS: Leisure-time physical activity - Prostate cancer - Meta-analysis

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Publication History

Article first published online: July 12, 2017
Manuscript accepted: July 10, 2017
Manuscript revised: March 3, 2017
Manuscript received: December 6, 2016

Cite this article as

Liu F, Wang J, Wu HL, Wang H, Wang JX, Zhou R et al. Leisure time physical activity and risk of prostate cancer: A dose-response meta-analysis. Minerva Urol Nefrol 2017 Jul 12. DOI: 10.23736/S0393-2249.17.02874-0

Corresponding author e-mail

Drwangjing@126.com