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MINERVA UROLOGICA E NEFROLOGICA
A Journal on Nephrology and Urology
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,536
Minerva Urologica e Nefrologica 2015 December;67(4):375-82
The role of fetuin-A in cardiac functions and metabolism in peritoneal dialysis patients
Aydin Z. 1, Ozturk S. 1, Celik C. 2, Gursu M. 1, Karadag S. 1, Yamak M. 2, Basinoglu F. 3, Gurdal A. 4, Sumnu A. 1, Cebeci E. 1, Sakci E. 2, Sar F. 2, Kazancioğlu R. 5 ✉
1 Department of Nephrology, Haseki Training and Research Hospital, Istanbul, Turkey;
2 Department of Internal Medicine, Haseki Training and Research Hospital, Istanbul, Turkey;
3 Department of Biochemistry, Haseki Training and Research Hospital, Istanbul, Turkey;
4 Department of Cardiology, Istanbul Medical Faculty of Istanbul University, Istanbul, Turkey;
5 Department of Nephrology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
AIM: Fetuin-A is a member of protease inhibitors that act as an inhibitor of vascular calcification. In our study, the relationship of fetuin-A with metabolic and echocardiographic parameters in peritoneal dialysis (PD) patients has been investigated.
METHODS: Besides demographic, clinical and laboratory data, fetuin-A level was recorded. Echocardiographic examinations were performed by the same operator.
RESULTS: Fifty-two chronic PD patients (mean age: 52.7±15.4 years) and 31 healthy volunteers (mean age: 41.3±10.7 years) were included. Fetuin-A levels were significantly lower in the patient group (57.5±31.5 ng/mL vs. 72.5±34.0 ng/mL, P=0.002). There was a significant relation between age and fetuin-A levels (P=0.025). Four patients with chronic heart failure had significantly lower fetuin-A levels compared with those without. There was no relation between fetuin-A levels and the presence of diabetes mellitus, left ventricular hypertrophy and ischemic heart disease. No relationship was detected between fetuin-A level and any echocardiographic parameter. Age and hematocrite were correlated negatively, and serum albumin positively with fetuin-A levels. On linear regression analysis, fetuin-A level was related with age, hematocrite and presence of heart failure.
CONCLUSION: PD patients with heart failure have significantly lower fetuin-A levels. Age is a main determinant of fetuin-A level and fetuin-A may act as a negative acute phase reactant in PD patients.