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MINERVA UROLOGICA E NEFROLOGICA

A Journal on Nephrology and Urology


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Minerva Urologica e Nefrologica 2013 June;65(2):133-55

Copyright © 2013 EDIZIONI MINERVA MEDICA

language: English

Testicular germ cell tumors. Current concepts and management strategies

Cost N. G.

Division of Urology, University of Cincinnati College of Medicine and the Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA


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Testicular germ cell tumors (T-GCTs) are the most common solid tumor in adolescent and young adult men. Due to the success of multidisciplinary management, the prognosis of all stages of T-GCT is quite good. The development of complimentary therapeutic strategies including modern cytotoxic chemotherapy regimens, appropriate utilization of radiotherapy, and timely surgical resection has made T-GCTs the model of a “curative” malignancy. Herein we review the background, epidemiology, and genetics of the disease, as well as an approach to its diagnosis and staging, including rationale for managing T-GCT in its various stages. In summary, while some areas in T-GCT care are debated, the vast majority of patients should be approached in a standardized manner which ensures optimal oncologic outcomes and minimal therapeutic morbidity.

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nicholas.cost@sbcglobal.net