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A Journal on Nephrology and Urology

Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,536

Frequency: Bi-Monthly

ISSN 0393-2249

Online ISSN 1827-1758


Minerva Urologica e Nefrologica 2013 June;65(2):117-23


Prostatitis and andrological implications

Wagenlehner F. 1, Pilatz A. 1, Linn T. 2, Diemer T. 1, Schuppe H. C. 1, Schagdarsurengin U. 1, Hossain H. 3, Meinhardt A. 5, Ellem S. 4, Risbridger G. 4, Weidner W. 1

1 Department of Urology Pediatric Urology and Andrology Justus‑Liebig‑University of Giessen Giessen, Germany;
2 Medical Clinic III: Internal Medicine Endocrinology/Diabetes Justus‑Liebig‑University, Giessen, Germany;
3 Institute for Medical Microbiology Justus‑Liebig University Giessen Giessen, Germany;
4 Prostate Cancer Research Group Department of Anatomy and Developmental Biology Monash University, Victoria, Australia;
5 Department of Anatomy and Cell Biology Faculty of Medicine Justus‑Liebig‑University of Giessen Giessen, Germany

Aim: The prostatitis syndrome is a frequent disease affecting men in their reproductive age. The prostatitis syndrome is classified according to the National Institutes of Health (NIH) definition. Andrological implications of the prostatitis syndrome might encompass fertility issues, sexual dysfunctions and endocrinological alterations and influences.
Methods: A medline query using the terms prostatitis AND andrological implication, fertility, sexual dysfunction or endocrinology was performed.
Results: Acute bacterial prostatitis and andrological implications have not been adequately addressed. Patients with chronic bacterial prostatitis and chronic pelvic pain syndrome have been investigated evaluating sperm parameters. Some studies showed impaired sperm parameters. In chronic bacterial prostatitis, half of the patients reveal significant bacteriospermia with still debatable deleterious effects on sperm quality. Few interventional studies have addressed fertility issues in those patients. Anti-inflammatory treatment perhaps could have a positive impact on sperm parameters. Sexual dysfunction can be described by different components such as erectile, ejaculatory, orgasmic and sexual desire dysfunctions. Sexual dysfunction in chronic prostatitis adds to the number of positive symptom phenotypes and correlates therefore with increasing symptom scores in patients with chronic prostatitis syndromes. However, prospective interventional studies on the role of sexual dysfunctions are missing. Hormones have been found to modulate the inflammatory response via different receptors, particularly via estrogen receptor alpha. This evidence, however, is mainly limited to pre-clinical studies currently.
Conclusion: Andrological implications are heterogenous and frequently described in patients with chronic prostatitis syndrome. Nonetheless, andrological factors have not been routinely addressed as primary variables in the different studies, which makes further research necessary.

language: English


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