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MINERVA UROLOGICA E NEFROLOGICA
A Journal on Nephrology and Urology
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,536
Minerva Urologica e Nefrologica 2008 September;60(3):141-5
IL-6, TNFα, IL-10 in the seminal plasma of patients with bacterial male accessory gland infections after sequential therapy
La Vignera S., Calogero A. E., Castiglione R., D’Agata R., Giammusso B., Condorelli R., Vicari E.
Endocrinology Section, Andrology and Internal Medicine Biomedical Science Department Garibaldi Hospital (Centre) University of Catania, Catania, Italy
Aim. In previous studies the authors have demonstrated a worse spermatic outcome associated to overproduction of ROS in infertile patients with urogenital infections extended to more glands (prostato-vesciculitis, PV) compared to what observed in patients with prostatitis (P) (cat II according to the National Institutes of Health [NIH]). Among the reasons of an inadequate post-therapeutical response, the duration of each therapeutical phase could be the only bias of empirism entrusted only to the monitoring of obvious “traditional” end-points, resulting underrated for various reasons (costs, lacking methodological standardization, choice of the cytokines to be monitored). The evaluation of other therapeutical endpoints (cytokine dosage in the seminal plasma; analysis of ROS) is therefore all important.
Methods. In order to evaluate how to optimize the therapeutic response in infertile patients with P o PV chronic-bacterical, the authors wanted to monitor the pattern of the pro-oxidants cytokines TNFα, IL-6 in the seminal plasma (met. sandwich ELISA high sensitivity <0.039 pg/mL, R&D System Europe Ltd, UK) and of IL-10 (chosen as antioxidant cytokine) after sequential therapy (antibiotic - non-steroidal anti-inflammatory drugs – antioxidant).
Results and conclusions. The modifications of the levels of TNFα, IL-6 ed IL-10 recorded in the present study during the sequential therapy for P or PV microbic offer some issues for reflection for interesting clinical-diagnostical implications: 1) possible revision of sequences and/or duration of the therapeutical phases in course of PV; and 2) the role to assign to the IL-10 (assumed as anti-inflammatory cytokine).