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CURRENT ISSUEMINERVA UROLOGICA E NEFROLOGICA

A Journal on Nephrology and Urology

Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,536

Frequency: Bi-Monthly

ISSN 0393-2249

Online ISSN 1827-1758

 

Minerva Urologica e Nefrologica 2008 June;60(2):123-35

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Spontaneous regression of lung metastases from renal cell carcinoma: the importance of immunogenetic factors and a review of the literature

Crisci A. 1, Corsale I. 2, Abrami F. 2, Politi L. 2, Andreani M. 2, Borgianni S. 2, Barale D. 2, Porfirio B. 3

1 Dipartimento di Area Critica Medico Chirurgica Urologia I Università degli Studi di Firenze, Firenze, Italia
2 Dipartimento di Chirurgia Toracica Università degli Studi di Firenze, Firenze, Italia
3 Dipartimento di Fisiopatologia Clinica Cattedra di Genetica Medica Università degli Studi di Firenze, Italia

Spontaneous regression of renal cell cancer (RCC) metastases most frequently occurs after nephrectomy, since reducing target size makes possible a more effective immune response. RCC is immunotherapy-sensitive, as are RCC metastases, especially metastases to the lungs (organs are rich in immune cells and continually exposed to antigens), which have an antigenic effect. Immunotherapy could be perfected if a renal antigen that could be incorporated into a vaccine were identified. This would have played an important role in treatment and follow-up. Vaccine therapy for RCC is no longer far out of reach. The characteristics of RCC make it a fertile field for the study of prometastatic and endogenous antiangiogenic factors.

language: Italian


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