Home > Journals > Minerva Urologica e Nefrologica > Past Issues > Minerva Urologica e Nefrologica 2003 June;55(2) > Minerva Urologica e Nefrologica 2003 June;55(2):111-8

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

MINERVA UROLOGICA E NEFROLOGICA

A Journal on Nephrology and Urology


Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,536


eTOC

 

REVIEWS  


Minerva Urologica e Nefrologica 2003 June;55(2):111-8

language: English

Acute renal allograft rejections, a role for statins?

Holdaas H. 1, Jardine A. 2

1 Depart­ment of Med­i­cine, Nation­al Hos­pi­tal, ­Oslo, Nor­way
2 Depart­ment of Med­i­cine and Ther­a­peu­tics, West­ern Infir­mary, Glasg­ow, UK


PDF  


Acute rejec­tion of kid­ney allo­grafts dur­ing the ­first ­months fol­low­ing trans­plan­ta­tion is one of the ­most impor­tant ­risk fac­tor for ­long-­term ­graft fail­ure. ­Some ­small ­open stud­ies ­have indi­cat­ed ­that 3-­hydroxy-3-meth­yl­glu­ta­ryl coen­zyme A (HMG-Co-A), sta­tins, ­might act as immu­no­sup­pres­sive ­agents, and ­reduce ­acute rejec­tion ­rates. More­over, the use of sta­tin in trans­plant recip­ients is ­quite com­mon, ­despite no ­data ­from pros­pec­tive ­large mul­ti-cen­tre stud­ies are avail­able to dem­on­strate any ben­e­fi­cial ­effect for ­acute rejec­tions or ­long-­term car­di­o­vas­cu­lar pro­tec­tion in ­this pop­u­la­tion. In ­this over­view, ­recent clin­i­cal and experi­men­tal ­data ­will be pro­vid­ed for assess­ing sta­tins as immu­no­sup­pres­sive agents. ­Although in ­vitro stud­ies ­have pro­vid­ed a theo­ret­i­cal ­basis for the use of sta­tins as immu­no­sup­pres­sive ­agents, ­more ­recent clin­i­cal pla­ce­bo con­trolled stud­ies ­have ­failed to con­firm the ­initial opti­mism of ­this ­effect of sta­tins.

top of page

Publication History

Cite this article as

Corresponding author e-mail