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Minerva Urologica e Nefrologica 2002 September;54(3):163-71

Copyright © 2002 EDIZIONI MINERVA MEDICA

language: English

Nuclear size measurements in collecting tubules of the rat kidney in establishing the effect of hypokinesia on the kidney morphology

Zorbas Y. G. 1, Afonin V. B. 1, Charapakhin K. P. 2, Denogratov S. D. 2

1 Kos­mic Biol­o­gy and Med­i­cine Insti­tute Kras­no ­Selo, ­Sofia, Bul­gar­ia
2 Hypo­ki­net­ic Phys­iol­o­gy Labor­a­to­ry Ath­ens, ­Greece


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Back­ground. Hypo­ki­ne­sia (­reduced ­motor activ­ity) induc­es sig­nif­i­cant tis­sue mor­pho­log­i­cal chang­es, how­ev­er, it is not ­known if hypo­ki­ne­sia (HK) ­could con­trib­ute to mor­pho­log­i­cal chang­es in the kid­ney. Meas­ur­ing the nucle­ar ­size in the ­inner medul­lary col­lect­ing ­ducts on the kid­ney of ­rats the aim of ­this inves­ti­ga­tion was to dis­close kid­ney mor­pho­log­i­cal chang­es dur­ing pro­longed HK.
Meth­ods. Stud­ies ­were ­done on 192 13-­week-old ­male ­rats (370 to 390 g) dur­ing 15 ­days pre-HK peri­od and 90 ­days HK peri­od. ­Rats ­were equal­ly divid­ed ­into 2 ­groups: vivar­i­um con­trol ­rats (VCR) and hypo­ki­net­ic ­rats (HKR). All HKR ­were ­kept in ­small indi­vid­u­al cag­es.
­Results. A sig­nif­i­cant (p<0.05) ­increase in ­size of col­lect­ing ­duct ­nuclei of the kid­ney, plas­ma aldos­te­rone (PA), plas­ma and uri­nary Sodium (Na) and Potassium (K) and ­fluid ­loss, a sig­nif­i­cant (p<0.05) ­decrease of ­fluid ­intake, ­body ­weight and plas­ma anti­diu­ret­ic hor­mone (ADH) ­observed in HKR ­when com­pared ­with ­their pre-HK val­ues and the val­ues in VCR. The meas­ured param­e­ters ­change insig­nif­i­cant­ly (p>0.05) in VCR ­when com­pared ­with ­their pre-HK val­ues.
Con­clu­sions. It was con­clud­ed ­that the nucle­ar ­size in the ­inner medul­lary col­lect­ing ­ducts of the kid­ney increas­es sig­nif­i­cant­ly dur­ing pro­longed HK. The rea­son for ­this reac­tion ­remains ­unclear.

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