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MINERVA UROLOGICA E NEFROLOGICA

A Journal on Nephrology and Urology


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Minerva Urologica e Nefrologica 2002 June;54(2):145-8

language: Italian

Treatment of post kidney transplantation erythrocytosis (PTE) with ACE inhibitors

Morale W., Puliatti C., Veroux P., Veroux M., Valvo C., Cappello D., Puliatti D., Francesco L. *

Policlinico Università di Catania Centro Trapianti di Rene - I Clinica Chirurgica
*Cattedra di Chirurgia Sostitutiva e dei Trapianti di Organo - Catania


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Back­ground. ­Post kid­ney trans­plan­ta­tion eryth­ro­cy­to­sis is a fre­quent com­pli­ca­tion in ­male sub­jects. In our expe­ri­ence, it ­occurs in approx­i­mate­ly 20% of trans­plant ­patients receiv­ing cyclo­spo­rine immu­no­sup­pres­sion ther­a­py.
Meth­ods. Twen­ty-two ­patients ­with ­post kid­ney trans­plan­ta­tion eryth­ro­cy­to­sis ­were treat­ed ­using ACE-inhib­i­tors (lisin­o­pril) at a ­dose of 2-5-5 mg/day for a ­mean peri­od of 15 ­months. ­Owing to the ­onset of col­lat­er­al ­effects, 27% of ­these ­patients request­ed the con­ver­sion of ACE ­into angio­ten­sin II recep­tor antag­o­nists (AII). Twen­ty out of 22 ­patients ­were ­male (90%).
­Results. Treat­ment result­ed in a 15% reduc­tion of hem­a­toc­rit val­ues com­pared to ­basal lev­els, ­which ­remained ­stable ­over ­time. No col­lat­er­al ­effects ­were record­ed, ­either for the kid­neys or in ­terms of hypo­ten­sion.
Con­clu­sions. ACE-inhib­i­tors (lisin­o­pril) or alter­na­tive­ly the use of angio­ten­sin II recep­tor antag­o­nists, ­like iosar­tan, at low dos­es, is an effec­tive and ­safe treat­ment for ­patients devel­op­ing ­post-trans­plan­ta­tion eryth­ro­cy­to­sis (PTE).

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