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A Journal on Nephrology and Urology

Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,536

Frequency: Bi-Monthly

ISSN 0393-2249

Online ISSN 1827-1758


Minerva Urologica e Nefrologica 2002 June;54(2):81-91


Stress response proteins and renal ischemia

Kelly K. J.

From the Indiana University School of Medicine Department of Medicine, Division of Nephrology Indianapolis, IN, USA

­Acute ­renal fail­ure is a fre­quent clin­i­cal ­entity ­with an increas­ing inci­dence and an unac­cept­ably ­high mor­tal­ity, yet ­there is no spe­cif­ic treat­ment. The induc­tion of ­stress ­response (heat ­shock) pro­teins (­HSPs) is a high­ly con­served ­response ­that pro­tects ­many ­cell ­types ­from ­diverse phys­io­log­i­cal and envi­ron­men­tal stres­sors. ­Diverse HSP fam­i­lies of dif­fer­ent siz­es func­tion as molec­u­lar chape­rones ­that facil­i­tate the fold­ing of ­enzymes and oth­er pro­teins ­into the func­tional con­for­ma­tion. ­After inju­ry, ­HSPs are ­believed to facil­i­tate the res­to­ra­tion of nor­mal func­tion by assist­ing in the refold­ing of dena­tured pro­teins and deg­ra­da­tion of irrep­a­ra­bly dam­aged pro­teins and tox­ic metab­olites, lim­i­ta­tion of aggre­ga­tion of dam­aged pep­tides and aid­ing the appro­pri­ate fold­ing of new­ly syn­the­sized essen­tial poly­pep­tides. We ­have recent­ly dem­on­strat­ed pro­tec­tion ­from the func­tion­al def­i­cits and his­to­log­ic evi­dence of experi­men­tal ischem­ic ­renal inju­ry ­with ­heat ­stress 6 ­hours but not 48 ­hours ­prior to the ischem­ic ­insult. Lim­i­ta­tion of the induc­tion of ­HSPs (­either ­with a ­short peri­od of hyper­ther­mia or phar­mac­o­log­i­cal­ly) atten­u­at­ed the pro­tec­tion ­observed. Oth­er inves­ti­ga­tors ­have dem­on­strat­ed a cor­re­la­tion ­between the lev­els of HSP 25 and ­renal ischem­ic pre­con­di­tion­ing in the ­mouse. Sev­er­al phar­mac­o­log­ic ­agents ­have ­been ­shown to ­increase HSP expres­sion. Enhance­ment of ­these endog­e­nous pro­tec­tive mech­a­nisms has poten­tial ben­e­fit in ­human dis­ease.

language: English


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