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MINERVA UROLOGICA E NEFROLOGICA
A Journal on Nephrology and Urology
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,536
Minerva Urologica e Nefrologica 2001 September;53(3):135-7
Erectile disfunction after non nerve-sparing radical pelvic surgery. Therapeutical experience with sildenafil and L-arginine evaluated by buckling-test
Mantovani F., Patelli E., Colombo F., Pozzoni F., Confalonieri S., Pisani E.
Istituto di Urologia IRCCS Ospedale Maggiore - Milano
Background. The patients who undergo radical pelvic surgery often found that sexual function is impaired. In this research hypothesis, we evaluated the efficacy of alternative therapy to conventional PGE 1 injections, such as the association of Sildenafil and L-Arginine. This association in based on the principle that L-Arginine, the precursor of nitric oxide, impoves the effect of Sildenafil, which is effective in the presence of nitric oxide.
Methods. The experimental plan was to make a comparative study of 2 random groups of patients selected from those undergoing radical cystectomies and prostatectomies over the past three years. 116 patients were elegible (64 prostatectomies and 52 cystectomies). The fìrst random group was treated with Sildenafil alone and the second with Sildenafil and L-Arginine. The efficacy of treatment was evaluated by the Buckling test (pressure threshold of cavernous flexation at penile axial rigidity) once-after ambulatorial administration and then by telephonic interview (subjective evaluation) after home administration.
Results. The starter dose was 50 mg and was inefficient in both groups (Buckling test between 0 and 250). 100-mg doses gave significant results (Buckling test > 500) in both groups, especially the second. Cardiopathic patients, diabetics and patients with retinal disorders were excluded from the study. The mean age of patients was 65 years.
Conclusions. The resumption of relatively satisfactory sexual activity was demonstrated using non-invasive pharmacological treatment.