Home > Journals > Minerva Urologica e Nefrologica > Past Issues > Minerva Urologica e Nefrologica 2000 December;52(4) > Minerva Urologica e Nefrologica 2000 December;52(4):219-22

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

MINERVA UROLOGICA E NEFROLOGICA

A Journal on Nephrology and Urology


Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,984


eTOC

 

TECHNOLOGY NEWS  


Minerva Urologica e Nefrologica 2000 December;52(4):219-22

Copyright © 2000 EDIZIONI MINERVA MEDICA

language: English

From the intestinal neobladder to the bioartificial bladder: remarks on some biological implications

Alberti C.

University of Parma (Italy) L.D. of Surgical Semeiotics


PDF  


In an attempt to avoid the complications associated with use of bowel for bladder augmentation or replacement (systemic metabolic imbalances, malignancy, etc.), various solutions have been proposed for an artificial orthotopic neobladder: total alloplastic prosthetic bladder in nonbiological material (silicon rubber, polyurethane, etc.); tissue-engineered bladder by the patient’s own urothelial – and smooth muscle – cells obtained by biopsy of a urinary segment with less neoplastic potential and cultured in vitro, then seeded onto biodegradable bladder-shaped scaffold, autografted in the original host; bladder augmentation or replacement using acellular matrix derived from small-intestinal submucosa or from bladder or ureter as a scaffold structure for the subsequent regrowth of functional organ. Tissue-engineering technology with autologous native cells is being undertaken for every type of organ within the urinary tract. At the present moment, other roads are less practicable, e.g. to obtain “spare bladders” from human therapeutic cloning or from transgenic-humanized animals.

top of page

Publication History

Cite this article as

Corresponding author e-mail