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MINERVA UROLOGICA E NEFROLOGICA
A Journal on Nephrology and Urology
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,536
Minerva Urologica e Nefrologica 2000 March;52(1):13-6
Metabolic effects of dietary salt manipulation in essential hypertensive patients
Boero R., Pignataro A., Bancale E. *, Campo A., Morelli E., Nigra M. *, Novarese M., Possamai D., Prodi E., Quarello F.
ASL 4 - Ospedale Giovanni Bosco - Torino Divisione di Nefrologia e Dialisi
* Laboratorio di Analisi Chimico-Cliniche
Background. To evaluate the metabolic effects of modification of sodium intake in patients with essential hypertension.
Methods. Thirteen patients with essential hypertension (10 M, median age 51 yrs, range 21-64) followed in random order a low-sodium and a high-sodium diet (50 mmol Na/day vs 250 mmol/day for two weeks each). At the end of each diet an evaluation was made of 24 hour blood pressure (ABPM, Spacelabs 90207) and serum concentration of: glucose, total and HDL cholesterol, uric acid, lipoproteins A, B, Lp(a), total proteins, albumin.
Results. Twenty-four hours systolic and diastolic BP were significantly higher at the end of high sodium diet than of low sodium diet [respectively 132 mmHg (120-161) vs 128 mmHg (109-150); p=0.008 and 84 mmHg (71-99) vs 81 mmHg (70-95); p=0.008)]. No significant variations were found as regards serum glucose and lipidic parameters between low and high sodium diets. Serum uric acid was significantly higher following low sodium diet [5.9 mg/dl (4.5-8) vs 4.6 mg/dl (3.4-6.5); p=0.003)], as well as serum total proteins [7.2 g/dl (6.9-8.2) vs 7 g/dl (6.5-7.8); p=0.027)]. A significant direct correlation was found between changes of uric acid and total proteins from low to high sodium diet (Spearman’s r=0.57; p=0.04).
Conclusions. In patients with essential hypertension a moderate dietary sodium restriction, able to reduce significantly 24 hours arterial pressure, does not worsen serum glucose nor lipids concentration.