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MINERVA STOMATOLOGICA

A Journal on Dentistry and Maxillofacial Surgery


Official Journal of the Italian Society of Odontostomatology and Maxillofacial Surgery
Indexed/Abstracted in: CAB, EMBASE, Index to Dental Literature, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index


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Minerva Stomatologica 2017 Jul 12

DOI: 10.23736/S0026-4970.17.04062-6

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Oxidative stress, antioxidants, and lipid profile in the serum and saliva of individuals with coronary heart disease: is there a link with periodontal health?

Natheer H. AL-RAWI 1 , Alaa M. SHAHID 2

1 Department of Oral & Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates; 2 Al-Yarmouk Hospital, Ministry of Health, Baghdad, Iraq


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BACKGROUND: Oxidative stresses and dyslipidemia are an important risk factor in the development of coronary atherosclerotic complications like angina pectoris and myocardial infarction. The aim of this study was to find the relationship between the salivary lipid profile, lipid peroxidation and antioxidants and the periodontal health status of patients with acute coronary heart disease.
METHODS: Forty s who had experienced a recent attack of angina pectoris or myocardial infarction and another 40 noncardiac patients matched for age, sex and residence (control) were recruited. The lipid profile level, lipid peroxidation and antioxidant status were measured in the serum and saliva of all participants together with lactate dehydrogenase (LDH) and C-reactive protein (CRP). The studied parameters were then correlated with the periodontal status of the participant using the clinical periodontal sum score (CPSS). A multiple linear regression was used to assess the net effect of each set of independent variables on the outcome variable using SPSS-21. A P value ≤ 0.05 was considered statistically significant.
RESULTS: Salivary total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C), Malondialdehyde (MDA), uric acid (UA), superoxide dismutase (SOD) and lactate dehydrogenase (LDH) levels increased with the upper tertile of the CPSS, while salivary high-density lipoprotein-cholesterol (HDL-C) decreased with the upper tertile of the CPSS.
CONCLUSION: Periodontal health status could be considered as an independent risk factor for acute coronary heart disease (CHD).


KEY WORDS: Myocardial infarction - Lipid profile - Antioxidants

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Publication History

Manuscript first published online: July 12, 2017
Manuscript accepted: July 05, 2017
Manuscript revised: June 28, 2017
Manuscript received: February 4, 2017

Cite this article as

H Al-Rawi N, Shahid AM. Oxidative stress, antioxidants, and lipid profile in the serum and saliva of individuals with coronary heart disease: is there a link with periodontal health?. Minerva Stomatol 2017 Jul 12. DOI: 10.23736/S0026-4970.17.04062-6

Corresponding author e-mail

nhabdulla@sharjah.ac.ae