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A Journal on Dentistry and Maxillofacial Surgery

Official Journal of the Italian Society of Odontostomatology and Maxillofacial Surgery
Indexed/Abstracted in: CAB, EMBASE, Index to Dental Literature, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index




Minerva Stomatologica 2011 January-February;60(1-2):87-92

language: English

Primary diffuse large B-cell lymphoma of the mandible. A case report

Pié-Sánchez J. 1, Petit J. 2, Figueiredo R. 1,3, Gay-Escoda C. 1,3,4,5

1 Oral Surgery and Implantology, University of Barcelona Dental School, Barcelona, Spain;
2 Clinical Hematology Service of the Catalan Institute of Oncology, L’Hospitalet de Llobregat, Llobregat, Spain;
3 IDIBELL Institute, Barcelona, Spain;
4 Oral and Maxillofacial Surgery, University of Barcelona Dental School, Barcelona, Spain;
5 Maxillofacial Surgery, Teknon Medical Center, Barcelona, Spain


Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma and is characterized by the appearance of rapidly developing tumor lesions in the lymph nodes, spleen, liver, bone marrow or other organs. Primary extranodal presentations of this entity in bone are rare (5% of all extranodal lymphomas) and their initial manifestation is usually in the form of a single bone lesion. This paper addresses a case of a 62-year-old male diagnosed with diffuse large B-cell lymphoma in the mandible. The patient had left mandibular swelling with intermittent paresthesia of the left lower lip and chin, without apparent neck adenopathies. No other locations were identified in the several exams performed, and the final diagnosis was an asymptomatic diffuse extranodal large B-cell lymphoma (IE-A) in the body of the left mandible. Four cycles of chemotherapy were given according to the R-CHOP protocol (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) plus external radiotherapy targeted to the involved site, resulting in complete remission of the tumor. Such lesions are fairly uncommon in daily clinical practice. However, considering their severity and the importance of an early diagnosis, such conditions should be included in the differential diagnosis of bone lesions in the orofacial region.

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