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A Journal on Dentistry and Maxillofacial Surgery
Minerva Stomatologica 2010 October;59(10):579-81
Orofacial granulomatosis of the lip: a report of 2 cases with histological and immunohistochemical analyses and intralesional corticotherapy
Martini M. Z., Galletta V. C., Pereira É. M., De Sousa S. C. O. M., Lemos C. A., Migliari D. A.
1 Department of Oral Diagnosis, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil
2 Department of Oral Pathology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil.
Orofacial granulomatosis is a generic term applied to manifestations of several diseases including sarcoidosis, Crohn’s disease, Melkersson-Rosenthal syndrome, cheilitis granulomatosa of Miescher, tuberculosis and foreign-body reactions. What bonds these diseases together is the presence of noncaseating granulomas. A typical clinical manifestation of orofacial granulomatosis is recurrent labial swellings that eventually persist. This article describes 2 cases of OG diagnosed with the aid of immunohistochemical analysis and successfully treated with intralesional steroids.