Home > Journals > Minerva Stomatologica > Past Issues > Minerva Stomatologica 2009 October;58(10) > Minerva Stomatologica 2009 October;58(10):501-18

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

MINERVA STOMATOLOGICA

A Journal on Dentistry and Maxillofacial Surgery


Official Journal of the Italian Society of Odontostomatology and Maxillofacial Surgery
Indexed/Abstracted in: CAB, EMBASE, Index to Dental Literature, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index


eTOC

 

REVIEWS  FREEfree


Minerva Stomatologica 2009 October;58(10):501-18

Copyright © 2009 EDIZIONI MINERVA MEDICA

language: English, Italian

Oral pemphigus

Mignogna M. D., Fortuna G., Leuci S.

Oral Medicine Unit, Department of Odontostomatologica and Maxillo-facial Science, School of Medicine and Surgery,“Federico II” University, Naples, Italy


FULL TEXT  


Pemphigus is a group of potentially life-threatening autoimmune diseases characterized by cutaneous and/or mucosal blistering, due to the presence circulating IgG antibodies directed against desmoglein 1 and 3 (Dsg 1 and 3). Differences in the particular distribution of these result in different clinical manifestations of the disease. The most common variant is pemphigus vulgaris (PV). There is a fairly strong genetic background to pemphigus with linkage to HLA class II alleles and ethnic groups such as Ashkenazi Jews and those of Mediterra-nean and Indian origin are especially liable. Oral lesions are commonly characterized by the presence of vesiculobullous and ulcerative lesions. Diagnosis is achieved via three different parameters: perilesional tissue biopsy, histological and immunological examinations. Serum autoantibodies to either Dsg1 or Dsg3 are best detected using both normal human skin and monkey esophagus or by enzyme-linked immunosorbent assay. The main aim of treatment is to reduce inflammatory re-sponse and autoantibody production, in order to achieve disease remission in a short time. Before the advent of corticosteroids, PV was typically fatal due to dehydration or secondary systemic infections. Current treatment is largely based on systemic immunosuppression using corticosteroids, with azathioprine or other adjuvants or alternatives. Nonetheless, newer therapies, such as intravenous immunoglobulins (IVIg) or anti-CD20 monoclonal antibodies (Rituximab), with potentially fewer adverse effects also appear promising.

top of page

Publication History

Cite this article as

Corresponding author e-mail

mignogna@unina.it