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A Journal on Dentistry and Maxillofacial Surgery

Official Journal of the Italian Society of Odontostomatology and Maxillofacial Surgery
Indexed/Abstracted in: CAB, EMBASE, Index to Dental Literature, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index




Minerva Stomatologica 2008 September;57(9):453-7

language: English

A rare case of sclerosing mucoepidermoid carcinoma arising in minor salivary glands with immunohistochemical evaluation

Aguiar M. C. F. 1, Bernardes V. F. 1 Cardoso S. V. 2, Barbosa A. A. 3, Mesquita R. A. 1, Carmo M. A. V. 1

1 Department of Oral Surgery, Oraò Medicine and Oral Pathology, School of Dentistry Universidade Federal de Minas Gerais Belo Horizonte, Brazil
2 Department of Oral and General Pathology School of Dentistry Universidade Federal de Uberlândia Uberlândia, Brazil
3 Department of Surgery, School of Medicine Universidade Federal de Minas Gerais Belo Horizonte, Brazil


Mucoepidermoid carcinomas (MECs) are the most common malignancy of the salivary glands demonstrating a wide range of histologic variants and behavior. However, the sclerosing mucoepidermoid carcinoma (SMEC), a morphologic variant of this tumor is extremely rare and has been described almost exclusively in the major glands. The prominent sclerosis observed may obscure its typical morphological feature resulting in a diagnostic challenge. We describe herein a case of SMEC in a 43-year-old-woman, occurring in the minor salivary glands of palate. To our knowledge only 13 cases have been reported until this moment, being only 2 in minor salivary glands. We also performed the immunohistochemical evaluation of c-erbB-2 and Ki-67, searching for an association with the histopathological findings and behavior.

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