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A Journal on Dentistry and Maxillofacial Surgery

Official Journal of the Italian Society of Odontostomatology and Maxillofacial Surgery
Indexed/Abstracted in: CAB, EMBASE, Index to Dental Literature, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index




Minerva Stomatologica 2008 March;57(3):133-7

language: English

Treatment of submandibular fibromatosis with chemotherapy and surgery. A case report

Otmani N. 1, Lamalmi N. 2, Khattab M. 1

1 Department of Pediatric Hemato-oncology Children’s Hospital, Rabat, Morocco
2 Department of Anatomic Pathology Children’s Hospital, Rabat, Morocco


Fibromatoses are a broad group of fibrous tissue proliferation that arise from the musculoaponeurotic structures. Because of the locally aggressive behaviour and the high recurrence rate of these tumors, various treatment options are suggested but there is still no optimal therapy for these diseases. This paper describes a case of infantile fibromatosis of the submandibular region, which was successfully treated with an interdisciplinary approach using chemotherapy and surgery. A three-year-old girl with a growing submandibular mass over a period of six months is described. The tumor was clinically aggressive, causing bone erosion and invading adjacent soft tissue structures. The diagnosis of infantile fibromatosis was established on histological and immunohistochemical findings. With a combined treatment based on “low-dose” chemotherapy including vinblastine and methotrexate and surgery; complete remission was achieved in 30 months. Manage-ment of head and neck fibromatoses in child-hood needs a specific approach. Combined treatment by chemotherapy and nonmutilating surgery seems to offer the best potential for cure.

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