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A Journal on Dentistry and Maxillofacial Surgery

Official Journal of the Italian Society of Odontostomatology and Maxillofacial Surgery
Indexed/Abstracted in: CAB, EMBASE, Index to Dental Literature, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index




Minerva Stomatologica 2007 May;56(5):293-302

language: English, Italian

Oral ulcers: three questions on their physiopathology

Campisi G. 1, Compilato D. 1, Cirillo N. 2, Ciavarella D. 3, Panzarella V. 1, Amato S. 4, Lo Muzio L. 3

1 “G. Messina” Department of Stomatological Sciences, University of Palermo, Palermo, Italy
2 Department of Experimental Medicine Second University of Naples, Naples, Italy
3 Department of Surgical Sciences University of Foggia, Foggia, Italy
4 Unit of Dermatology, ARNAS Ospedale Civico e Fatebenefratelli G. Di Cristina e Maurizio Ascoli, Palermo, Italy


Ulcers and/or erosions can be the final common manifestation, often clinically indistinguishable, of a wide and complex spectrum of conditions including traumatic lesions, infectious, vesiculo-bullous, neoplastic and gastrointestinal diseases. Their formation represents the final outcome of a complex and finely orchestrated phenomenon involving both epithelial lining and chorion. Reduction of blood flow, cytokine production, cell death, wound repair, all participate to the dynamic process which we define as “ulcer”. However, little is known about the mechanisms which crucially contribute in determining the phenomenology of ulcer, and some questions still remain unsolved. This paper aims to explain the pathophysiology of oral ulcers attempting to answer three questions: the mechanism of ulcer development, the site of appearance, and the factors which determine the severity and healing time of ulcerative lesions.

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