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A Journal on Dentistry and Maxillofacial Surgery

Official Journal of the Italian Society of Odontostomatology and Maxillofacial Surgery
Indexed/Abstracted in: CAB, EMBASE, Index to Dental Literature, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index




Minerva Stomatologica 2006 July-August;55(7-8):423-30

language: English, Italian

Granular cells tumour in the oral cavity: report of eleven cases treated with laser surgery

Angiero F. 1, Crippa R. 2, Stefani M. 1

1 Oral Pathology Section Department of Anatomic Pathology University of Milan, Milan, Italy
2 Department of Oral Pathology and Lasertherapy Italian Stomatological Institute, Milan, Italy


Aim. The aim of this paper is to examine the clinical and histological feature of oral tumours of neural derivation and discuss their treatment.
Methods. Between 1999 and 2004, 11 patients (6 females, 5 males; age range 28-66 years) were treated for tumours classified as being of neural origin; they were all myoblastomas or granular cells tumours (ex Abrikossoff tumour). Eight were located on the dorsum of the tongue, 2 on the lateral margin and 1 on the right buccal mucosa. In all cases the mass appeared nodular, single and firm; patients were treated in a single session by excisional resection with 808 and 830 diode laser.
Results. During follow-up, which ranged from 5 months to 5 years, there was no indication of tumour recurrence. Histopathological analysis of haematoxylin and eosin–stained sections showed all specimens to exhibit features typical of GCT; 6 tumours were well circumscribed, whereas 5 infiltrated adjacent connective tissue, muscle fibres and nerve bundles. In 10 of the 11 cases, the immunohistochemical S-100 protein stain was available and appeared positive. Pseudo-epitheliomatous hyperplasia of different degrees was present in 5 patients, along the overlying epithelium.
Conclusions. Granular cell tumour is a benign neoplasm with a tendency to relapse if not completely removed. The usefulness of laser in the surgical treatment of these tumours particularly if small in size, is underlined.

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