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A Journal on Dentistry and Maxillofacial Surgery

Official Journal of the Italian Society of Odontostomatology and Maxillofacial Surgery
Indexed/Abstracted in: CAB, EMBASE, Index to Dental Literature, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index




Minerva Stomatologica 2006 January-February;55(1-2):59-65


language: English, Italian

Gingival overgrowth in renal transplant recipients induced by pharmacological treatment. Review of the literature

Grassi F. R. 1, Pappalardo S. 2, Baglìo O. A. 2, Frateiacci A. 3, Scortichini A. 3, Papa F. 1, De Benedittis M. 1, Petruzzi M. 1

1 Unit of Periodontology II and Prosthesis I Department of Odontostomatology and Dentistry University of Bari, Bari, Italy 2 Unit of Odontostomatology II Department of Medico-Surgical Specialties University of Catania, Catania, Italy 3 Unit of Periodontology Department of Odontostomatological Sciences University of Ancona, Ancona, Italy


Patients who undergo a renal transplant also require a pharmacological immunosuppressor therapy with cyclosporine (CsA) as well as anti-hypertensive calcium channel-blockers (CCBs); the former suppresses interferon and interleukin-2 production thus interfering with T cell cell-mediated activity, while the latter are used in order to counteract the nephrotoxicity of CsA which causes the local release, of thromboxane A2 with vascular vasoconstriction in the kidney. The use of both these drugs, particularly if used in association, leads to the onset of a clinical picture of variable entity, characterized mainly by a hypertrophy originating usually at the level of interdental papillae, and more pronounced in the anterior maxillary areas and the vestibular surfaces of the teeth, in a more or less symptomatic manner. The therapy is above all preventive, with an appropriate oral hygiene program, both professionally as well as at home, and with the use of substitutive drugs that do not present such side effects.

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