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A Journal on Dentistry and Maxillofacial Surgery
Minerva Stomatologica 2003 June;52(6):273-8
Systemic administration of capsaicin for the treatment of the Burning Mouth Syndrome
Lauritano D., Petruzzi M., Baldoni M.
Aim. Burning mouth syndrome could be considered an expression of atypical facial pain. The recent neuropathological findings in BMS may suggest the need for alternative the-rapies. This paper aims to evaluate if syste-mic capsaicin could be used for BMS the- rapy.
Methods. Eighty-four BMS patients (19 males and 63 females, aged 36 to 74 years, mean 54.6) were referred to the Oral Medicine and Oral Pathology Department, Dental University Institute, Milan-Bicocca University. They were divided in 2 groups: 1st Group: the first group (42 patients) received 3 capsules of capsaicin (50 mg of powder of red pepper with 0,25% of capsaicin) a day for one month. 2nd Group: the control group (42 patients) received 3 capsules of placebo (empty capsules) a day for one month. The intensity of pain was measured on the visuo-analogical scale VAS. T test of Student was applied to analyse results of VAS. P values of less than 0.05 were interpreted as significant, and the level in confidence intervals was 95%.
Results. Significant differences were noted between the two groups at the end of our study (p<0.05). No important side effects were reported.
Conclusion. Systemic capsaicin could be considered a successful therapeutical approach for BMS patients.