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MINERVA STOMATOLOGICA

A Journal on Dentistry and Maxillofacial Surgery


Official Journal of the Italian Society of Odontostomatology and Maxillofacial Surgery
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Minerva Stomatologica 2002 September;51(9):405-10

language: English

Burning Mounth Syndrome (BMS): an open trial of comparative efficacy of alfa-lipoic acid (thioctic acid) with other therapies

Femiano F.


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Background. Alpha-lipoic acid (ALA) is a potent antioxidant mitochondrial coenzyme, trometamol salt of thioctic acid, shown in clinical studies to be neuroprotective and in a preliminary study to have an effect on the symptomatology of Burning Mouth Syndrome (BMS).
Methods. We were interested in extending our studies as to whether alfa-lipoic acid might improve the symptomatology in BMS and therefore carried out a larger open controlled clinical study on the effects of alfa-lipoic acid on BMS symptomatology.
Results. We have examined the effects on 4 groups of 20 patients with BMS of ALA, compared with bethanecol, Biotene and placebo, and found ALA of remarkable benefit with minimal adverse effects.
Conclusions. These results suggest that double-blind randomized controlled multicenter studies of ALA are indicated.

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