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In the present study, a rare pathology, described for the first time in 1973 has been examined. In particular, the nosologic picture of the disease, the etiopathogenetic hypotheses, symptoms and diagnostic procedures reported in the literature have been analysed. The case of a man showing a neo-formation, in the midline region of the hard palate, that appeared only following ingestion of very hot food is examined. The surgical procedure is reported and discussed in detail, and the histopathological analysis showing a necrotizing sialometaplasia is reported. Prognosis and possible therapeutic approaches are also discussed. Finally, the attention has been focused on the histological similitary between this pathology and squamous cell carcinoma or epidermoid carcinomas.