Home > Journals > Minerva Stomatologica > Past Issues > Minerva Stomatologica 2001 November-December;50(11-12) > Minerva Stomatologica 2001 November-December;50(11-12):345-50

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

MINERVA STOMATOLOGICA

A Journal on Dentistry and Maxillofacial Surgery


Official Journal of the Italian Society of Odontostomatology and Maxillofacial Surgery
Indexed/Abstracted in: CAB, EMBASE, Index to Dental Literature, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index


eTOC

 

ORIGINAL ARTICLES  


Minerva Stomatologica 2001 November-December;50(11-12):345-50

language: English

Phagocytosis and killing of Candida albicans of polymorphonuclear cells in patients with organ transplant of periodontal disease

Maccarinelli G., Belotti R., Savoldi E., Gervasoni M., Cocchi D.


PDF  


Background. The easiest defence system carried out by the organism, the inflammatory response, happens with the support of phagocyting cells: the polymorphonuclear leukocytes (PMNL) or neutrophils are the most important cell line acting as the first defence of the organism against bacterial agents. Previous studies have shown a correlation between a reduction of the immune function and development of periodontal disease. Furthermore, it is well known that transplant patients show a variety of oral lesions as a consequence of their therapy, in particular to immunosuppressive drugs. The aim of this study is to evaluate the phagocytosis and ''killing'' functions of PMNL in transplant patients and in patients with periodontal disease in comparison with a group of healthy subjects.
Methods. PMNL, were isolated by spontaneous sedimentation from heparinized blood and centrifugation of plasma on density medium. Phagocytosis rate was expressed as the percentage of Candida albicans phagocyted after 20' incubation and phagocyting PMNLs. Intracellular killing was expressed as the percentage of yeast cells killed.
Results. We did not find a significant decrease of phagocytosis in transplant patients and patients with periodontal disease while these two groups of patients showed a decrease of PMNL ''killing'' activity in respect to healthy controls, an effect which was unrelated to the severity of periodontal disease.
Conclusions. These results suggest that a reduction of ''killing'' activity, either spontaneous or drug-induced, would contribute to the development of periodontal disease.

top of page

Publication History

Cite this article as

Corresponding author e-mail