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A Journal on Dentistry and Maxillofacial Surgery
Minerva Stomatologica 2000 November-December;49(11-12):561-8
Efficacy and tolerance of ketoprofen lysinate solution in acute inflammation of the mouth in orthodontic therapy. Single-blind parallel study versus benzidamine hydrochloride
Lauritano D., Spadari F., Salvato A.
Background. The study was carried out to value the analgesic efficacy of ketoprofen lysinate solution administered by oral route. Ketoprofen lysinate solution is an efficacious topical drug for pain relief and control of inflammation agents.
Methods. The study was carried out in 120 patients submitted to orthodontic therapy by oral route, under single blind conditions at the ''San Raffaele'' Hospital in Milan. The 120 patients who underwent orthodonthic therapy were males and females, from 18 to 40 years old. One group was treated with ketoprofen lysinate solution at the doses of 160 mg in 100 ml (60 patients), the other group with benzidamine hydrochloride 15 ml (60 patients), twice a day for seven days. Pain relief and control of inflammation agents have been evaluated.
Results. The study showed ketoprofen lysinate solution to be very effective for pain relief and control of inflammation agents. In fact, on the basis of the visual analogue scale of Scott-Huskisson and of the patient's judgement, ketoprofen proved significantly better than benzidamine.
Conclusions. The analgesic efficacy of ketoprofen lysinate solution administered by oral route was prompt and long lasting than benzidamine. Both treaments were very well tolerated.