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A Journal on Dentistry and Maxillofacial Surgery
Minerva Stomatologica 2000 January-February;49(1-2):1-8
language: English, Italian
Anti-HCV antibodies are detectable in the gingival crevicular fluid of HCV positive subjects
Montebugnoli L., Dolci G.
Aims. To verify the possible of identifying HCV-positive subjects by assaying hepatitis C immunological markers in the gingival crevicular fluid.
Methods. Ten HCV-EIA-positive subjects and ten HCV-EIA negative subjects were enrolled. One specimen each of blood, saliva and gengival crevicular fluid were collected from each subjects, and anti-HCV antibodies determined using a rapid test described elsewhere.
Results. The test was highly sensitive and specific (100%) on whole blood, but unable to detect anti-HCV antibodies in any specimen on whole saliva; anti-HCV antibodies were detected in about 80% of gingival crevicular fluid specimens from HCV-positive subjects, suggesting that the HCV virus and anti-HCV antibodies may enter the pounth in the gingival crevicular fluid and then spread outside the mouth via the saliva.
Conclusions. The gingival crevicular fluid could be a valid alternative to blood for detection of HCV-positive subjects; in association with the HCV rapid test this may be a useful procedure for use in routine dental practice.