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A Journal on Dentistry and Maxillofacial Surgery
Minerva Stomatologica 1999 December;48(12):567-76
language: English, Italian
Bioactivity of chitosan in dentistry. Preliminary data on chitosan-based cements
Mattioli Belmonte M., De Benedittis A., Mongiorgi R., Gandolfi M. G., Giardino R., Biagini G., Valdrè G., Muzzarelli RAA, Prati C., Dolci G.
Background. The chemical association of chitosan with inorganic salts, such as calcium phosphate, finds a promising application in dentistry as room-temperature self-hardening cement. We present the physical, chemical and crystallographic characterization of newly-developed cements made of 1) calcium-phosphate and a chitosan gel obtained by acetic acid treatment, and 2) calcium phosphate and a chitosan gel obtained by ascorbic acid treatment. Both cements are self-hardening at room temperature.
Methods. The cements were characterized by X-ray diffractography, scanning electron microscopy and fluorine-selective electrode analysis.
Results. The chitosan-hydroxyapatite cements had hardness comparable to spongy bone and above that of PMMA.
Conclusions. The cements are promising for application in endodontics and restorative dentistry.