Home > Journals > Minerva Psichiatrica > Past Issues > Minerva Psichiatrica 2013 March;54(1) > Minerva Psichiatrica 2013 March;54(1):83-92

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

MINERVA PSICHIATRICA

A Journal on Psychiatry, Psychology and Psychopharmacology


Official Journal of the Italian Society of Social Psychiatry
Indexed/Abstracted in: EMBASE, e-psyche, PsycINFO, Scopus, Emerging Sources Citation Index


eTOC

 

ORIGINAL ARTICLES  


Minerva Psichiatrica 2013 March;54(1):83-92

Copyright © 2013 EDIZIONI MINERVA MEDICA

language: Italian

Mixed mania and antidepressants: a clinical study on a sample of bipolar inpatients

Bertetto N., Rosso G., Blengino G., Bogetto F., Maina G

Servizio per i Disturbi Depressivi e d’Ansia, Dipartimento di Neuroscienze, Università di Torino, Torino, Italia


PDF  


Aim: The aim of this study was to elucidate the relationship between mixed manic or hypomanic episodes and the use of antidepressants before their onset.
Methods: We enrolled a sample of 117 bipolar inpatients with a DSM-IV manic or hypomanic episode. Patients have been grouped according to the presence or absence of mixed features: mixed (hypo)mania was defined as a (hypo)manic episode with evidence of at least three depressive symptoms, according to criteria proposed by Elroy et al. A comparison between the two subgroups has been performed on socio-demographic and clinical characteristics and on psychopharmacologic treatments during the month before the onset of the symptomatology.
Results: Fifty-three percent of patients with mixed (hypo)mania and 25.5% patients with “pure” (hypo)mania assumed at least one antidepressant before the onset of the symptomatology (P=0.003). No statistically significant differences were found concerning mood stabilizers, antipsychotics and benzodiazepine. Further, patients with mixed (hypo)mania differ from patients with “pure” (hypo)manic episodes concerning the following domains: higher number of previous mixed episodes (1.15 vs. 0.33: P<0.001), higher rate of suicide attempt in current episode (6% vs. 0%: P=0.013) and of psychiatric lifetime comorbidity (66.7% vs. 29.4%: P<0.001), higher mean score at the CGI-BP (4.76 vs. 4.27, P=0.003) and lower mean score at the GAF (41.61 vs. 48.78, P=0.003).
Conclusion: Our data support the hypothesis that the use of antidepressants is related to the onset of mixed (hypo)manic episodes more than pure (hypo)manic episodes. This is a further evidence that the use of antidepressants should be limited as much as possible in bipolar disorder, especially in euthymic patient with previous mixed episodes or suicide attempts.

top of page

Publication History

Cite this article as

Corresponding author e-mail