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A Journal on Psychiatry, Psychology and Psychopharmacology
Official Journal of the Italian Society of Social Psychiatry
Indexed/Abstracted in: EMBASE, e-psyche, PsycINFO, Scopus, Emerging Sources Citation Index
SCHIZOPHRENIA: A CLOSER LOOK
Minerva Psichiatrica 2012 September;53(3):171-84
Treatment effects in schizophrenia: evidence from neuroimaging
Karch S., Keeser D., Pogarell O.
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany
Cognitive deficits as well as difficulties in emotion recognition in schizophrenic patients have shown to be related to dysfunctions, especially in frontal, striatal and parietal areas as well as the amygdala. In the present review the effect of various treatment strategies and trainings on these processes will be addressed. Cognitive improvements along with functional alterations, especially in the anterior cingulate cortex, the dorsolateral prefrontal cortex, the inferior frontal gyrus, the inferior parietal gyrus as well as striatal regions seem to be associated with medication of atypical neuroleptics. Functional adaptations in frontal areas were also demonstrated after emotion training, cognitive behavioural training, repetitive TMS and real time fMRI neurofeedback. Apart from this, predominantly parietal and occipital regions appear to be of importance. These findings support the hypothesis that improvements in the symptomatology are related to neurobiological modifications.