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A Journal on Psychiatry, Psychology and Psychopharmacology

Official Journal of the Italian Society of Social Psychiatry
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Minerva Psichiatrica 2011 June;52(2):71-9

language: Italian

Metabolic syndrome and psychiatric disorders: comparison between bipolar disorder and obsessive-compulsive disorder

Chiarle A., Albert U., D’ambrosio V., De Cori D., Salvi V., Maina G., Bogetto F.

Servizio per i Disturbi Depressivi e d’Ansia, Dipartimento di Neuroscienze,, Università degli Studi di Torino, Torino, Italia


Aim. A constellation of cardiovascular risk factors concurs in determining the so-called metabolic syndrome (MS), a condition narrowly correlated to an increased odd of multisystemic diseases. Several studies have found rates of MS remarkably higher in patients with bipolar disorder (BD) than in the general population, whereas the current literature still lacks in studies of comparison between BD and the so-called “minor disorders”, as, for example, anxiety disorders. Aim of our study was to investigate the prevalence and the socio-demographic and clinical correlates of MS in a sample of patients with BD, and to compare MS rates between subjects with BD and obsessive-compulsive disorder (OCD).
Methods. Two groups of patients were consecutively admitted: 1) subjects with BD I, II or NOS (not otherwise specified); 2) subjects with OCD. Socio-demographic, clinical, physiological and medical information, lifestyles, and comorbidity with cardiovascular diseases were collected for each subject. The prevalence of MS was assessed according to the NCEP ATP-III modified criteria.
Results. MS was investigated in 227 patients and a significantly higher prevalence was found in the bipolar sample (27.8% vs. 11.9%, P=0.045); the two groups were also differentiated by the frequency of unhealthy lifestyles.
Conclusion. MS is more prevalent in Italian patients with BD than in the general population, and this rate is still significantly higher even if compared to another psychiatric diagnosis such as OCD. As expected, the role of healthy and unhealthy lifestyles is of great importance.

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