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A Journal on Psychiatry, Psychology and Psychopharmacology

Official Journal of the Italian Society of Social Psychiatry
Indexed/Abstracted in: EMBASE, e-psyche, PsycINFO, Scopus, Emerging Sources Citation Index




Minerva Psichiatrica 2010 December;51(4):237-45


language: Italian

Psychobiological predictors of outcome in gastric bypass

Leombruni P., Migliore F., Lavagnino L., Gastaldi F., NicotraB., Ottone L., Fassino S.

Dipartimento di Neuroscienze, Università di Torino, Torino, Italia, Centro Pilota Regionale per i DCA, Azienda Ospedaliero Universitaria, S. Giovanni Battista, Torino, Italia


Aim. At present, bariatric surgery is the treatment of choice for morbid obesity, but it does not lead to equal results in every patient. Several non surgical and psychological factors appear to influence the patient’s ability to adjust to the postoperative condition, but reliable predictors are lacking. The aim of this study was to assess whether psychobiological presurgical variables can predict the outcome of gastric bypass (GBP) at two years.
Methods. Thirty-nine morbidly obese adults underwent GBP. They were administered a battery of self-report questionnaires in order to assess personality (Temperament and Character Inventory, TCI), eating psychopathology (Eating Disorder Inventory, EDI-2; Binge Eating Scale, BES; Body Shape Questionnaire, BSQ) and general psychopathology (STAXI, Beck Depression Inventory, BDI; Symptom Check-List-90, SCL-90 and SF-36). Weight loss was evaluated at 3 ,6, 12 and 24 months and excess weight loss (EWL) over 50% was employed as outcome. Patients were subdivided in two groups on the basis of outcome and associations between outcome and presurgical variables were investigated.
Results. A satisfactory weight loss was reached by 84,6% of patients. Presurgical BMI and persistence at TCI seem to be predictors of two-year outcome regarding EWL. Demographic variables and the presence of binge eating do not predict outcome at two years.
Conclusion. GBP was effective for the majority of patients. Although future studies with a larger sample and a longer follow-up are necessary to confirm the associations we found, personality emerges as a predictor of outcome at two years of follow-up.

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