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Minerva Psichiatrica 2010 March;51(1):37-41

language: English

Cerebrospinal fluid biomarkers for vascular dementia

Mattsson N., Zetterberg H.

Institution of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden


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Vascular dementia (VaD) is one of the most common forms of dementia, second only to Alzheimer’s disease (AD). Diagnosis may be difficult, in particular with differentiation towards AD. Pathological processes in the brain are reflected in the cerebrospinal fluid (CSF). Therefore, CSF analyses may be used to aid the clinician in dementia diagnostics. This mini-review covers the main CSF measurements usable to differentiate VaD from other causes of cognitive decline. Topics include albumin ratio for monitoring blood-brain barrier function, total-tau and neurofilament light for axonal damage, phospho-tau for differential diagnosis towards AD and CSF signs of neuroinflammation.

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