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Minerva Psichiatrica 2010 March;51(1):9-25

language: English

Genetics of vascular dementia

Murray M. E. 1, Meschia J. F. 2, Dickson D. W. 1, Ross O. A. 1

1 Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
2 Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, FL, USA


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Genetic studies are transforming the way we diagnose, evaluate and treat patients. The era of genome-wide association studies promised to discover common risk variants in heterogeneous disorders where previous small-scale association studies had on the whole failed. However, as we enter the post-association era a degree of disappointment is felt regarding the lack of risk factors with large effect for a number of disorders including vascular diseases. Vascular disorders are sporadic by nature, though a familial component has been observed. This review will focus on vascular dementia, the genetic risk factors for vascular disorders and highlight how new technologies may overcome the limitations of genome-wide association and nominate those genes that influence disease risk.

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