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A Journal on Psychiatry, Psychology and Psychopharmacology

Official Journal of the Italian Society of Social Psychiatry
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Minerva Psichiatrica 2009 June;50(2):99-106

language: Italian

Quality of life and psychopathology in schizophrenia

Giugiario M., Birindelli N., Mingrone C., Montemagni C., Sigaudo M., Zappia S., Rocca P.

Sezione di Psichiatria Dipartimento di Neuroscienze Università degli Studi di Torino, Torino, Italia


Aim. The aim of this study was to analyze the relationship between psychopathology and quality of life in a population of outpatients with stable schizophrenia.
Methods. For this study 92 consecutive outpatients with stable schizophrenia were enrolled. Psychiatric assessment included the Positive and Negative Syndrome Scale, the Calgary Depression Scale for Schizophrenia, the Clinical Global Impression-Severity scale and the Quality of Life Scale (QLS). All clinical and demographic variables significantly related to QLS scores in this sample were subsequently analysed using a multiple stepwise regression to assess their independent contribution to quality of life.
Results. Negative symptoms and severity of illness appeared to have an influence on QLS total score (explaining a variance of 38%) and intrapsychic foundations domain of QLS while severity of illness alone had a role on instrumental role functioning and common objects and activities domains of QLS. Positive symptoms had an influence limited to interpersonal relationships domain of QLS, together with negative symptoms. Finally, depressive symptoms seemed not to be related to quality of life in our sample.
Conclusion. These findings suggest that negative symptoms and severity of illness had a predominant role in influencing quality of life of these patients and that different domains of quality of life are likely to have different predictors. Also, it seems reasonable to highlight that treatments to improve quality of life in stable chronic schizophrenia should focus particularly on negative symptoms.

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