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A Journal on Psychiatry, Psychology and Psychopharmacology

Official Journal of the Italian Society of Social Psychiatry
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Minerva Psichiatrica 2007 June;48(2):195-210

language: Italian

Obsessive-compulsive disorder and related disorders: clinical and biological updating and future indications

Dell’Osso B. 1,2, Mundo E. 1, Buoli M. 1, Hollander E. 2, Altamura A. C. 1

1 Centro per la Diagnosi e il Trattamento dei Disturbi Depressivi Dipartimento di Scienze Clinche Luigi Sacco Università degli Studi di Milano, Milano
2 Department of Psychiatry, Compulsive, Impulsive and Anxiety Disorders Program Mount Sinai School of Medicine, New York, USA


Obsessive-compulsive disorder (OCD) is one of the most common and disabling psychiatric disorders, being associated with high rates of comorbidity and treatment-resistance. Over the last two decades, several acquisitions in the biological and clinical fields have allowed to point out several overlapping issues among OCD and other psychiatric disorders belonging to different diagnostic groups. These conditions, referred as obsessive-compulsive related disorders (OCRDs), include many distinct psychiatric conditions (i.e. somatoform disorders, eating disorders, impulse control disorders and some neurological conditions) which have overlapping symptoms and compulsive qualities with OCD. Even though effective treatments exist, OCD and OCRDs are often underdiagnosed and undertreated. Serotonin reuptake inhibitors and cognitive-behavioural therapy represent the first-line treatment for OCD and related disorders. The time and the doses of medications used in the treatment of OCD and related disorders differ from those recommended in depressive disorders. In patients with partial or no response to first-line treatments, augmentation strategies and brain stimulation techniques might be considered.

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