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A Journal on Psychiatry, Psychology and Psychopharmacology
Official Journal of the Italian Society of Social Psychiatry
Indexed/Abstracted in: EMBASE, e-psyche, PsycINFO, Scopus, Emerging Sources Citation Index
Minerva Psichiatrica 2003 September;44(3):189-90
Awareness of involuntary movenents in Huntington disease with olanzapine. A case report
Fogliani A. M., Di Giorgio A., Bonomo V.
We describe a case of a 51-year-old woman affected by Huntington disease who presented choreoatetosic movements that had appeared 4 years previously. She also experienced concentration and attention difficulties, agitation, aggression and insomnia that had begun 5 months earlier. She was treated with olanzapine at 5 mg daily that induced a slight improvement in her motor functioning. The drug was then increased to 10 mg/day. After this treatment she gradually also developed a subjective experience of illness and started to be aware of her involuntary movements with global functional improvement. We argue that olanzapine efficacy on cognitive impairment has similarity to its pharmacological effect on negative psychotic symptoms.