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Minerva Psichiatrica 2003 March;44(1):47-54

language: Italian

A case of Asperger syndrome diagnosed in adulthood and associated to pericentric inversion of chromosome 9

Verri A. P., Cimbro C., Ramponi A.


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Asperger's syndrome pioneering paper was published in 1944. The term Asperger Syndrome is fast becoming used to describe certain patients who have never been easy to classify, but who seem to constitute a recognizable typology. Since 1994 it belongs to the DSM IV classification with the following criteria: impaired social interaction, abnormal non-verbal communication, special interests, clumsiness; typical is the triad of socialization, imagination and communication impairments. We describe the case of a 42 year-old man with Asperger syndrome diagnosed only in adulthood and associated with a pericentric inversion of chromosome 9 [46, XY, inv(9) (p11q13)]. In literature, different researches show the association between the pericentric inversion of chromosome 9 and some mental disorders. It is possible that cases considered as autistic or psychotic could be instead Asperger's cases, where the developmental history was not enough taken into consideration.

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