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A Journal on Psychiatry, Psychology and Psychopharmacology
Official Journal of the Italian Society of Social Psychiatry
Indexed/Abstracted in: EMBASE, e-psyche, PsycINFO, Scopus, Emerging Sources Citation Index
Minerva Psichiatrica 2003 March;44(1):39-46
Antipsycotis and methabolic involvement. A evaluation of the cases observed at the Psychiatric Unit of the Aosta Hospital
Spanarello S., Beoni A. M., Mina G., Colotto A.
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Backgrounds. The aim of this paper was to compare, among the case series of the Psychiatry Department, the various antipsychotic active principles and evaluate any dysmetabolic implications in order to identify hypothetical guidelines that, at the same time, also considered other parameters such as alimentation and lifestyles.
Methods. The retrospective study was based on the examination of the databases and clinical records of the Psychiatry Department in Aosta, and the patients were selected according to diagnosis and the presence of periodic ponderal and hematochemical evaluations, with particular reference to glycemia, cholesterolemia and triglyceridemia values. More-over, the existence or not of risk factors such as obesity, diabetes or hypercholesterolemia familiarity was taken into consideration.
The sample was subdivided into groups depending on the antipsychotic active principle used and then the groups were assembled in two larger ones, according to whether typical or atypical antipsychotic drugs were used for the treatment.
Results. The results did not show significant statistical correlations between the use of atypical antipsychotics and hyperglycemia. There was, however, a positive correlation between the use of atypical antipsychotics and ponderal and/or hyperlipidemia increase.
Conclusions. The evaluations of this observation study lead the authors to conclude that hyperglicemia, hyperlipidemia and ponderal increase are phenomena linked to multifactor genesis, genetic aspect and lifestyle. The improvement in the quality of life and the better compliance with the therapy obtained with the atypical antipsychotics therefore become important elements in the evaluation of effective therapeutic protocols.