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A Journal on Psychiatry, Psychology and Psychopharmacology
Official Journal of the Italian Society of Social Psychiatry
Indexed/Abstracted in: EMBASE, e-psyche, PsycINFO, Scopus, Emerging Sources Citation Index
Minerva Psichiatrica 2002 June;43(2):77-84
Six-months tolerability of SSRIs treatment
Berardi S., Maina G., Bogetto F.
Background. SSRIs represent an important advance in the pharmacotherapy of mood and the other disorders. Although the safety of SSRIs is higher than tricyclic antidepressants (TCA) they have side effects that should be considered. The aim of this study is to describe the prevalence of side effects during a six-months treatment with SSRIs in a population of 266 outpatients with diagnosis of mood disorder.
Methods. Two hundred and sixty-six outpatients with mood disorder were consecutively investigated. Patients were interviewed with a semistructured clinical interview for the assessment of demographic data, pharmachological therapy, side effects during six months treatment, weight, height, BMI. The following rating scale were included: Hamilton rating scale for depression (HAM-D) and Hamilton rating scale for anxiety (HAM-A).
Results. SSRIs present side effects and their prevalence in this study is in agreement with literature data.
Conclusions. Even if adverse events are a problem for patients' compliance, SSRIs are significantly better tolerated than tricyclic antidepressants and there are no differences in efficacy between these two classes of antidepressants.