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Official Journal of the Italian Society of Social Psychiatry
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Minerva Psichiatrica 2001 June;42(2):119-24

language: Italian

Use of risperidone in the treatment of aggressive behaviour in mentally retarded patients

La Malfa G., Bertelli M., Conte M., Salvini R., Cabras P. L.


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Background. Aim of the present study is to evaluate the efficacy and tolerability of risperidone in controlling aggressive behaviour in adults with mental retardation.
Methods. Eighteen patients have been assessed for aggressivity through the Handicap Behaviour and Skills schedules (HBSs), for psychopathological aspects through the Psychopa-thologic Instrument for Mentally Retarded Adults (PIMRA), and for general clinic through Clinical Global Impression scale (CGIs). Patients were assessed before and after three months of treatment with flexible dose of risperidone (mean 2.0±1.0 mg/day).
Results. Scores of all the scales showed to be significantly lower after the three months of therapy. Data seem to confirm the literature on the efficacy of risperidone in controlling aggressive behaviour in mentally retarded persons.
Conclusions. The question if such an action on aggressivity is direct of by an emprovement of psychic disorders still remain open.

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