Advanced Search

Home > Journals > Minerva Pneumologica > Past Issues > Minerva Pneumologica 2016 September;55(3) > Minerva Pneumologica 2016 September;55(3):55-63

ISSUES AND ARTICLES   MOST READ   eTOC

CURRENT ISSUEMINERVA PNEUMOLOGICA

A Journal on Diseases of the Respiratory System

Official Journal of the Italian Society of Thoracic Endoscopy
Indexed/Abstracted in: EMBASE, Scopus

Frequency: Quarterly

ISSN 0026-4954

Online ISSN 1827-1723

 

Minerva Pneumologica 2016 September;55(3):55-63

    REVIEWS

Effects of cardiovascular drugs on respiratory mechanics: measurements by end-inflation occlusion in a rat model

Alessandro RUBINI

Section of Physiology, Department of Biomedical Sciences, University of Padua, Padua, Italy

The effects of some drugs of cardiovascular interest on respiratory mechanics which are described in the literature are reviewed, with particular attention to recently published results obtained by the end-inflation method on the rat. A description of this method is reported, which introduced the possibility to measure, together with the “ohmic” airway resistance and the respiratory system elastance, the additional “visco-elastic” resistance due to stress-relaxation. The latter represents a complex phenomenon most biological tissues exhibit, including respiratory system tissues: due to their visco-elastic properties, the tissues do not maintain constant stress under constant deformation, but slowly relax to a lower value. In the respiratory system, the visco-elastic pressure dissipation is responsible of a great amount of the total pressure that the inspiratory muscles have to develop to inflate the lungs. Recent data from the literature indicate that: 1) angiotensin-converting enzyme (ACE ) inhibition (captopril) causes a reduction of both the “ohmic” and the “visco-elastic” respiratory system resistances, leaving unaltered elastance; 2) amiodarone acutely increases both the “ohmic” and “visco-elastic” resistances, again leaving unaltered elastance; 3) nifedipine decreases the “ohmic” resistance and the elastance, while no significant effects were reported on the “visco-elastic” resistance. Drugs of cardiovascular interest often exhibit interesting effects on respiratory mechanics. Possible implications for the clinical usage of these drugs are suggested.

language: English


FULL TEXT  REPRINTS

top of page