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A Journal on Diseases of the Respiratory System

Official Journal of the Italian Society of Thoracic Endoscopy
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index




Minerva Pneumologica 2013 March;52(1):27-38

language: English

Non-invasive ventilation in amyotrophic lateral sclerosis/motor neurone disease

Oliver D. 1, 2, Faull C. 3, 4

1 Palliative Medicine, Wisdom Hospice, Rochester, UK;
2 Centre for Professional Practice, University of Kent;
3 Palliative Medicine, LOROS, Hospice Care for Leicester, Leicestershire and Rutland, UK;
4 Centre for Promotion of Excellence in Palliative Care, De Montfort University, Leicester, UK


Non-invasive ventilation (NIV) is now widely used in the support of people with amyotrophic lateral sclerosis/motor neurone disease (ALS/MND). Studies have shown that NIV does increase survival and improve quality of life for patients with respiratory insufficiency due to respiratory muscle dysfunction. There is the need to monitor respiratory function for ALS patients, using forced vital capacity or sniff nasal pressure and pulse oximetry. Careful assessment and introduction of NIV is necessary for these patients and discussion about the progression of the disease and consideration of advance care planning is essential.

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