Home > Journals > Minerva Pneumologica > Past Issues > Minerva Pneumologica 2011 June;50(2) > Minerva Pneumologica 2011 June;50(2):83-92





A Journal on Diseases of the Respiratory System

Official Journal of the Italian Society of Thoracic Endoscopy
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index




Minerva Pneumologica 2011 June;50(2):83-92

language: English

Antibiotic therapy of healthcare-associated pneumonia

Falcone M. 1, Kollef M. H. 2

1 Department of Public Health and Infectious Diseases, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy
2 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, MO, USA


The 2005 American Thoracic Society and Infectious Diseases Society of America (ATS/IDSA) pneumonia guidelines incorporated for the first time a new concept of pneumonia called healthcare associated pneumonia (HCAP). This type of infection develops in patients, classically defined as “community acquired pneumonia”, who have recent or chronic contact with the healthcare system and that appear to be at increased risk of infection with multi-drug resistant (MDR) pathogens. Recent studies have shown that this type of infection is distinct from “true CAP“ in terms of epidemiology, etiology and clinical outcome. Analysis of multi-institutional clinical data showed that mortality in patients with HCAP is higher than those with CAP, and that HCAP patients have an increased likelihood to receive inappropriate initial antibiotic treatment. To increase the likelihood that appropriate initial antibiotic treatment will be prescribed, the selection of initial empiric therapy must be patient oriented and institution specific, and determined according to local prevalence and susceptibility patterns. A review of available clinical data about HCAP treatment was conducted to determine effective empiric antibiotic strategies in order to improve clinical outcomes.

top of page

Publication History

Cite this article as

Corresponding author e-mail