Home > Journals > Minerva Pneumologica > Past Issues > Minerva Pneumologica 2010 December;49(4) > Minerva Pneumologica 2010 June;49(2):271-83

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

MINERVA PNEUMOLOGICA

A Journal on Diseases of the Respiratory System


Official Journal of the Italian Society of Thoracic Endoscopy
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index


eTOC

 

REVIEWS  WHAT’S NEW IN RESPIRATORY MEDICINE IN 2010 - PART II


Minerva Pneumologica 2010 June;49(2):271-83

language: English

Therapy for pulmonary hypertension

Dweik R. A.

Pulmonary Vascular Program, Department of Pulmonary, Allergy, and Critical Care Medicine/Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA


PDF  


The treatment of pulmonary arterial hypertension (PAH) is a testament to the success of modern medicine. One of its distinguishing features is that it is based on our knowledge and understanding of the ptahobiologic basis of this disease. Discoveries in three main pathobiologic pathways (nitric oxide, endothelin and prostacyclin) have revolutionized our approach to the treatment of PAH and allowed the development of effective therapies that have changed the course of this previously uniformly fatal disease. Based on our understanding of the disease, several targeted treatment options are currently available and include parenteral and inhaled prostanoids, oral endothelin receptor antagonists and oral phosphodiesterase type-5 inhibitors. Due to their complex care, patients with PAH should be referred to centers with expertise in pulmonary hypertension. Newer and probably more effective therapies are being developed and / or tested based on our improved understanding of the contributions and underlying mechanisms of certain pathobiologic features of the disease including cell proliferation and remodeling. Future therapies will likely reflect our improved understanding of the proliferative and vascular remodeling pathways and improved phenotyping of the disease.

top of page

Publication History

Cite this article as

Corresponding author e-mail