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A Journal on Diseases of the Respiratory System

Official Journal of the Italian Society of Thoracic Endoscopy
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index




Minerva Pneumologica 2010 September;49(3):143-5

language: English

Assessment of T4 lung cancer with adjacent organ invasion

Iwazaki M., Inoue H.

Division of General Thoracic Surgery, Department of Surgery, Tokai University School of Medicine, Kanagawa, Japan


Aim. Because of the poor results of treatment of T4 lung cancer by any other method except surgery, there have been hardly any report of long-term survival. However, although they represent only a minority of the cases treated surgically, there have been cases of long-term survival without any evidence of recurrence or metastasis, and it is particularly noteworthy that many reports have recognized the significance of surgical treatment for lung cancer in which mediastinal invasion was observed.
Methods. Between 1984 and 2004 there were 16 cases of T4 lung cancer with invasion of adjacent organs that were treated surgically in our Department, and in 9 of them (7 cases of squamous cell carcinoma and 2 cases of adenocarcinoma) combined resection of adjacent organs (relatively radical resection) was performed, and it was possible to perform complete resection.
Results. The results in those 9 cases were a 5-year or longer survival in 3 patients, a less than 5-year survival in 5 patients (cancer deaths on postoperative days [PODs] 377, 312, 159, and 125 and pneumonia death on POD 37).
Conclusion. Recurrence-free period was 32 months after surgery for squamous cell carcinoma in 1 patient who is still alive.

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